Tauro-β-muricholic acid

Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM) . Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential[1][2].

Product Specifications

CAS Number

[25696-60-0]

Product Name Alternative

TβMCA

UNSPSC

12352211

Target

Apoptosis; FXR

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tauro-β-muricholic-acid.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@]([C@H]([C@H]([C@]1([H])C[C@@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)C

Molecular Formula

C26H45NO7S

Molecular Weight

515.70

References & Citations

[1]Denk GU, et al. Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential. Biochem Biophys Res Commun. 2012 Aug 10;424 (4) :758-64.|[2]Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17 (2) :225-35.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Citation 01

Cell. 2025 Aug 21;188 (17) :4530-4548.e25.|Cell Host Microbe. 2024 Feb 14;32 (2) :191-208.e9.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|World J Gastrointest Oncol. 2025 Aug 15;17 (8) :107453.