Burimamide
Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768)[2].
Product Specifications
CAS Number
34970-69-9
UNSPSC
12352005
Target
Adrenergic Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/burimamide.html
Smiles
S=C(NCCCCC1=CN=CN1)NC
Molecular Formula
C9H16N4S
Molecular Weight
212.32
References & Citations
[1]Brimblecombe RW, et al. The pharmacology of burimamide and metiamide, two histamine H2-receptor antagonists. Fed Proc. 1976 Jun;35 (8) :1931-4.|[2]Gupta SC, et al. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem. 2013 Nov 8;288 (45) :32343-32356.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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