GLPG0634 analog

GLPG0634 analog (Compoun 176) is a broad spectrum JAK inhibitor with IC50 values of [1].

Product Specifications

CAS Number

[1206101-20-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GLPG0634-analog.html

Concentration

10mM

Purity

98.07

Solubility

DMSO : ≥ 53 mg/mL

Smiles

O=C(C1CC1)NC2=NN3C(C4=CC=C(OCC5=CC=C(C#N)N=C5)C=C4)=CC=CC3=N2

Molecular Formula

C23H18N6O2

Molecular Weight

410.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Christel Jeanne Marie Menet, et al. Novel compounds useful for the treatment of degenerative and inflammatory diseases. WO2010010190A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK1; JAK2; JAK3; Tyk2

Available Sizes

Curated Selection

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