BGC20-761

BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM) . BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1].

Product Specifications

CAS Number

[17375-63-2]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bgc20-761.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCC1=C(C2=CC=CC=C2)NC3=C1C=C(OC)C=C3

Molecular Formula

C19H22N2O

Molecular Weight

294.39

References & Citations

[1]Ellen S Mitchell, et al. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology. 2006 Mar;50 (4) :412-20.