TH6342
TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/th6342.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=CC=C1)=C1C(N=C2NCCC3=NC=CC=C3)=CN4C2=NC=C4
Molecular Formula
C19H16ClN5
Molecular Weight
349.82
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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