Broussonin A
Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].
Product Specifications
CAS Number
73731-87-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/broussonin-a.html
Purity
97
Solubility
10 mM in DMSO
Smiles
OC1=CC(OC)=CC=C1CCCC2=CC=C(O)C=C2
Molecular Formula
C16H18O3
Molecular Weight
258.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26 (4) :1194-1205.|[2]Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. |[3]Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
BChE
Available Sizes
Frequently Asked Questions
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