ROR gamma T Recombinant Rabbit Monoclonal Antibody [PSH04-38]
RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of the nuclear receptor family of transcription factors. It is mainly expressed in immune cells (Th17 cells) and it also regulates circadian rhythms. It may be involved in the progression of certain types of cancer. Two isoforms are produced from the same RORC gene, probably by selection of alternative promoters. RORγ (also referred to as RORγ1) – produced from an mRNA containing exons 1 to 11. RORγt (also known as RORγ2) – produced from an mRNA identical to that of RORγ, except that the two 5'-most exons are replaced by an alternative exon, located downstream in the gene. This causes a different, shorter N-terminus.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
RORC, NR1F3, RORG, RZRG
Swiss Prot
P51449 Human,
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Rat
Immunogen
Recombinant protein within human ROR gamma T aa 101-300 / 497 (P51449-2).
Isotype
IgG
Clone
PSH04-38
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
HCT 116 cell lysate, rat thymus tissue lysate, human thymus tissue, rat thymus tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 58 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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