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LY377604

LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.

Product Specifications

CAS Number

[204592-94-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/LY377604.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(OC2=CC=C(CC(C)(NC[C@H](O)COC3=CC=CC(N4)=C3C5=C4C=CC=C5)C)C=C2)N=C1)N

Molecular Formula

C31H32N4O4

Molecular Weight

524.61

References & Citations

[1]Jesudason CD, et al. Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2 (8) :583-6.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

β adrenergic receptor

Available Sizes

Curated Selection

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