J208
J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT) . J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs) [1].
Product Specifications
CAS Number
2116468-11-0
UNSPSC
12352005
Target
Apoptosis; DNA Methyltransferase; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/j208.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CN(C(N1)=O)CC2=CC=C(C=C2)C3=CN(N=N3)CCCCCCC(NO)=O
Molecular Formula
C20H24N6O4
Molecular Weight
412.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
Frequently Asked Questions
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