J208

J208 is a dual inhibitor for histone deacetylase (HDAC) and DNA methyltransferase (DNMT) . J208 inhibits proliferation of cancer cells, as well as the migration/invasion of triple-negative breast cancer (TNBC) cells. J208 induces apoptosis, arrests the cell cycle at G0/G1 phase. J2008 activates the innate immune signalling pathway in TNBC, by inducing the expression of endogenous retroviruses (ERVs) [1].

Product Specifications

CAS Number

[2116468-11-0]

UNSPSC

12352005

Target

Apoptosis; DNA Methyltransferase; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/j208.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CN(C(N1)=O)CC2=CC=C(C=C2)C3=CN(N=N3)CCCCCCC(NO)=O

Molecular Formula

C20H24N6O4

Molecular Weight

412.44

References & Citations

[1]Fan W, et al., Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer. Eur J Pharm Sci. 2024 Jun 1;197:106767.