Butylphthalide
Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
Product Specifications
CAS Number
6066-49-5
Product Name Alternative
3-n-Butylphthalide; 3-Butylphthalide
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
P38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Butylphthalide.html
Purity
99.98
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1OC(CCCC)C2=C1C=CC=C2
Molecular Formula
C12H14O2
Molecular Weight
190.24
Precautions
H315, H319, H335
References & Citations
[1]Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl) . 2013;126 (18) :3405-10.|[2]Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9 (7) :719-26.|[3]Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12 (31) :5995-6004.|[4]Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36 (3) :224-33.|[5]Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W. Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (Engl) . 2019;132 (12) :1467-1477.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
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