Butylphthalide

Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.

Product Specifications

CAS Number

[6066-49-5]

Product Name Alternative

3-n-Butylphthalide; 3-Butylphthalide

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

P38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Butylphthalide.html

Purity

99.98

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1OC(CCCC)C2=C1C=CC=C2

Molecular Formula

C12H14O2

Molecular Weight

190.24

Precautions

H315, H319, H335

References & Citations

[1]Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl) . 2013;126 (18) :3405-10.|[2]Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9 (7) :719-26.|[3]Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12 (31) :5995-6004.|[4]Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36 (3) :224-33.|[5]Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W. Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (Engl) . 2019;132 (12) :1467-1477.