HAChE-IN-8
HAChE-IN-8 (Compound S-12) is a orally effective and selective inhibitor of hAChE (IC50=0.486 μM) . hAChE-IN-8 also inhibits BACE-1 (IC50=0.542 μM), and does not inhibit Dyrk1A (IC50>10 μM) . hAChE-IN-8 can reduce Aβ aggregation, has good blood-brain barrier penetration. hAChE-IN-8 is mainly used in Alzheimer's disease research[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; DYRK
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-8.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(NC(CN2N=C(C(C3=CC=CC=C3)=NC2=O)C4=CC=CC=C4)=O)=CC(OC)=C1
Molecular Formula
C25H22N4O4
Molecular Weight
442.47
References & Citations
[1]Waiker DK, et al. Design, synthesis, and biological evaluation of some 2- (3-oxo-5,6-diphenyl-1,2,4-triazin-2 (3H) -yl) -N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy. Eur J Med Chem. 2024 May 5;271:116409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; DYRK1
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