(S) -Verapamil (hydrochloride)

(S) -Verapamil hydrochloride (S (-) -Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S) -Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

Product Specifications

CAS Number

[36622-28-3]

Product Name Alternative

(S) - (-) -Verapamil (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Calcium Channel; Leukotriene Receptor; P-glycoprotein

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-verapamil-hydrochloride.html

Purity

98.30

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C=CC(CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

Molecular Formula

C27H39ClN2O4

Molecular Weight

491.06

Precautions

H301

References & Citations

[1]Perrotton T, et al. (R) - and (S) -verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282 (43) :31542-8. Epub 2007 Jul 22.|[2]Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75 (4) :298-309.