7-Methylguanosine

7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects[1][2].

Product Specifications

CAS Number

[20244-86-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-Methylguanosine.html

Purity

98.08

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=[N+]2C)NC(N)=N1

Molecular Formula

C11H16N5O5+

Molecular Weight

298.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'- (1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26 (1) :191-199.|[2]Tomikawa C. 7-Methylguanosine Modifications in Transfer RNA (tRNA) . Int J Mol Sci. 2018 Dec 17;19 (12) :4080.