Dimesna
Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.
Product Specifications
CAS Number
16208-51-8
Product Name Alternative
BNP-7787
UNSPSC
12352100
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dimesna.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 68 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=S(CCSSCCS(=O)(O[Na])=O)(O[Na])=O
Molecular Formula
C4H8Na2O6S4
Molecular Weight
326.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Parker AR, et al. BNP7787-mediated modulation of paclitaxel- and cisplatin-induced aberrant microtubule protein polymerization in vitro. Mol Cancer Ther. 2010 Sep;9 (9) :2558-2567.|[2]Hausheer FH, et al.Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidase. Cancer Chemother Pharmacol. 2010 Apr;65 (5) :941-951.|[3]Cutler MJ, et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52 (4) :530-542.|[4]Habs MR, et al. Prevention of urinary bladder tumors in cyclophosphamide-treated rats by additional medication with the uroprotectors sodium 2-mercaptoethane sulfonate (mesna) and disodium 2,2'-dithio-bis-ethane sulfonate (dimesna) . Cancer. 1983 Feb 15;51 (4) :606-609.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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