(Rac) -Tavapadon

(Rac) -Tavapadon ((Rac) -PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac) -Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM) . (Rac) -Tavapadon has antiparkinsonian activity[1].

Product Specifications

CAS Number

[1643462-64-9]

Product Name Alternative

(Rac) -PF-06649751; (Rac) -CVL-751

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Arrestin; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-tavapadon.html

Purity

99.87

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O

Molecular Formula

C19H16F3N3O3

Molecular Weight

391.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10 (9) :4160-4182.