(Rac) -Tavapadon
(Rac) -Tavapadon ((Rac) -PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac) -Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM) . (Rac) -Tavapadon has antiparkinsonian activity[1].
Product Specifications
CAS Number
[1643462-64-9]
Product Name Alternative
(Rac) -PF-06649751; (Rac) -CVL-751
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Arrestin; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-tavapadon.html
Purity
99.87
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O
Molecular Formula
C19H16F3N3O3
Molecular Weight
391.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
D1 Receptor
Available Sizes
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