Human / Mouse / Rat GDF-8 Protein, Tag Free

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

Product Specifications

Background

Specifications

This protein carries no "tag". The protein has a calculated MW of 12.4 kDa. The protein migrates as 12.0 kDa under reducing (R) condition, and 11 kDa and 25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Accession Number

O14793

Expression Region

Asp 267 - Ser 375

Host

CHO

Target

GDF-8

Conjugation

Unconjugated

Tag

Native

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 1 μg/mL (100 μL/well) can bind Biotinylated Human Activin RIIB Protein, Fc,Avitag (Cat. No. ACB-H82F3) with a linear range of 0.1-8 ng/mL (QC tested).