Manganese (chloride)

Manganese chloride is an orally active MRI liver contrast agent. Manganese chloride induces Apoptosis and activates the mTOR signaling pathway. Manganese chloride induces cognitive impairment, promotes hematopoietic recovery, and reduces radiation-induced bone marrow and brain damage. It can be used for the study of renal impairment[1][2][3][4][5][6].

Product Specifications

CAS Number

[7773-01-5]

Product Name Alternative

Manganese dichloride

UNSPSC

12352300

Hazard Statement

H301, H318, H373, H411

Target

Apoptosis; Biochemical Assay Reagents; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Others; PI3K/Akt/mTOR

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/manganese-chloride.html

Purity

99.1

Solubility

1 M HCl : 150 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCL)

Smiles

Cl[Mn]Cl

Molecular Formula

Cl2Mn

Molecular Weight

125.84

Precautions

H301, H318, H373, H411

References & Citations

[1]Brismar TB, et al. Oral Manganese Chloride Tetrahydrate: A Novel Magnetic Resonance Liver Imaging Agent for Patients With Renal Impairment: Efficacy, Safety, and Clinical Implication. Invest Radiol. 2024 Feb 1;59 (2) :197-205.|[2]Cen Y, et al. Manganese induces neuronal apoptosis by activating mTOR signaling pathway in vitro and in vivo. Food Chem Toxicol. 2024 Mar;185:114508.|[3]Liang J, et al. Effects and mechanisms of water extract of Uraria crinit a on manganese chloride-induced apoptosis in SH-SY5Y cells. CyTA-Journal of Food, 2025, 23 (1) : 2463499. |[4]Hood MN, et al. Preliminary Promising Findings for Manganese Chloride as a Novel Radiation Countermeasure Against Acute Radiation Syndrome. Mil Med. 2024 Aug 19;189 (Suppl 3) :598-607. |[5]Salami AT, et al. Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways. Biol Trace Elem Res. 2025 Aug;203 (8) :4164-4182. |[6]Hussein A S A, et al. Quercetin or Rosmary extract mitigates Manganese chloride-induced Neurotoxicity through Regulation of DNA Methylation and Histone Acetylation and alleviation of apoptosis in rats. Journal of Advanced Veterinary Research, 2024, 14 (6) : 930-935.