Chimmitecan
Chimmitecan ((S) -9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].
Product Specifications
CAS Number
[185425-25-6]
Product Name Alternative
(S) -9-Allyl-10-Hydroxycamptothecin
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chimmitecan.html
Purity
98.96
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1[C@](CC)(C2=C(C(N3CC4=CC5=C(C(O)=CC=C5N=C4C3=C2)CC=C)=O)CO1)O
Molecular Formula
C23H20N2O5
Molecular Weight
404.42
Precautions
H301
References & Citations
[1]Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13 (4) :1298-307.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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