Chimmitecan

Chimmitecan ((S) -9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].

Product Specifications

CAS Number

[185425-25-6]

Product Name Alternative

(S) -9-Allyl-10-Hydroxycamptothecin

UNSPSC

12352005

Hazard Statement

H301

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chimmitecan.html

Purity

98.96

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1[C@](CC)(C2=C(C(N3CC4=CC5=C(C(O)=CC=C5N=C4C3=C2)CC=C)=O)CO1)O

Molecular Formula

C23H20N2O5

Molecular Weight

404.42

Precautions

H301

References & Citations

[1]Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13 (4) :1298-307.