Ipriflavone

Ipriflavone is a synthetic isoflavone derivative used to suppress bone resorption.

Product Specifications

CAS Number

[35212-22-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Ipriflavone.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=CC=C2)=COC3=CC(OC(C)C)=CC=C13

Molecular Formula

C18H16O3

Molecular Weight

280.32

Precautions

H315, H319, H335

References & Citations

[1]Iisaki T, et al. Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model. Int J Cancer. 2002 Aug 1;100 (4) :381-7.|[2]Hagiwara H, et al. Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells. J Biochem. 1999 Jul;126 (1) :168-73.|[3]Civitelli R, et al. Ipriflavone improves bone density and biomechanical properties of adult male rat bones. Calcif Tissue Int. 1995 Mar;56 (3) :215-9.|[4]Monostory K, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol. 1998 Feb;123 (4) :605-10.