CX-6258 (hydrochloride hydrate)

CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1].

Product Specifications

CAS Number

[1353858-99-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CX-6258-hydrochloride-hydrate.html

Concentration

10mM

Purity

99.23

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC2=CC=C(Cl)C=C2/C1=C\C3=CC=C(C4=CC=CC(C(N5CCCN(C)CC5)=O)=C4)O3.[H]Cl.O

Molecular Formula

C26H27Cl2N3O4

Molecular Weight

516.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Mustapha Haddach, Jerome Michaux, Michael K, Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139|[2]Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114 (5) :1050-7.