(Z/E) -GW406108X

(Z/E) -GW406108X is a mixture of different configurations of GW406108X (HY-115570) . GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM[1].

Product Specifications

CAS Number

[265098-01-9]

Product Name Alternative

(Z/E) -GW108X

UNSPSC

12352005

Target

Autophagy; Kinesin; ULK

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-e-gw406108x.html

Smiles

O=C1NC2=CC=C(C(C3=CC=CO3)=O)C=C2/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4

Molecular Formula

C20H11Cl2NO4

Molecular Weight

400.21

References & Citations

[1]Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477 (4) :801-814.|[2]Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29 (2) :148-154.