LH-RH (4-10)

LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes[1].

Product Specifications

CAS Number

[51776-33-1]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/lh-rh-4-10.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](N)CO)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(NCC(N)=O)=O)=O)=O)=O)=O

Molecular Formula

C33H53N11O9

Molecular Weight

747.84

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yang X, et al. Enzymatic degradation of luteinizing hormone releasing hormone (LHRH) /[D-Ala6]-LHRH in lung pneumocytes. Pharm Res. 1998 Sep;15 (9) :1480-4. |[2]Talwar GP, et al. Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression. Proc Natl Acad Sci U S A. 1985 Feb;82 (4) :1228-31.