Mouse CDNF Protein, His Tag (MALS verified)

Mouse CDNF, His Tag (CDF-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Leu 187 (Accession # Q8CC36).

Product Specifications

Background

CDNF is a member of the ARMET family and acts as a trophic factor for dopamine neurons. CDNF inhibits the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When CDNF controlled after 6-OHDA-lesioning, it reestablishes the dopaminergic function and inhibits the degeneration of dopaminergic neurons in substantia nigra. CDNF is universally expressed in neuronal and non-neuronal tissues. The highest levels in the brain are found in the optic nerve and corpus callosum.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 21-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Expression Region

Gln 25 - Leu 187

Host

HEK 293

Target

CDNF

Conjugation

Unconjugated

Tag

C-10×His

Source

Mouse

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.