Butylphthalide-d9

Butylphthalide-d9 (3-n-Butylphthalide-d9) is deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models[1].

Product Specifications

CAS Number

[2251692-52-9]

Product Name Alternative

3-n-Butylphthalide-d9; 3-Butylphthalide-d9

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Neurological Disease

Smiles

O=C1C2=CC=CC=C2C(O1)C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H]

Molecular Formula

C12H5D9O2

Molecular Weight

199.29

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W. Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (Engl) . 2019;132 (12) :1467-1477. |[3]Cui LY, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl) . 2013;126 (18) :3405-10.|[4]Zhao W, et al. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9 (7) :719-26.|[5]Wang X, et al. Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents. Org Biomol Chem. 2014 Aug 21;12 (31) :5995-6004.|[6]Wang F, et al. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36 (3) :224-33.