EGFR-IN-127
Product Specifications
UNSPSC Description
EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC)[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-127.html
Smiles
O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O
Molecular Weight
525.49
References & Citations
[1]Liang-Liang Guo, et al. Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines. Bioorg Med Chem Lett. 2024 Sep 14:113:129961.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168112/EGFR-IN-127-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168112/
Clinical Information
No Development Reported
Curated Selection
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