EGFR-IN-127

EGFR-IN-127 is an ATP-competitive EGFR inhibitor with IC50s of 136.3 nM and 161. 2 nM for EGFRdel19 and EGFRdel19/T790M/C797S, respectively. EGFR-IN-127 has the potential for the study of non-small-cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-127.html

Smiles

O=C(O)CN(CCN(CC(O)=O)C1)CC(NC2=CC3=C(N=CN=C3NC4=CC(F)=CC=C4)C=C2NC1=O)=O

Molecular Formula

C24H24FN7O6

Molecular Weight

525.49

References & Citations

[1]Liang-Liang Guo, et al. Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines. Bioorg Med Chem Lett. 2024 Sep 14:113:129961.