Biotinylated Human CCR8 Protein, His, Flag Tag&Avitag™ (Detergent)

Biotinylated Human CCR8 Protein, His, Flag Tag&Avitag (CC8-H82D3) is expressed from human 293 cells (HEK293) . It is a membrane protein, contains complete wild type 7-transmembrane domans (TMD) and extracellular doman (ECD) .

Product Specifications

Background

This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs) . CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine) . It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I.

Specifications

This protein carries a polyhistidine tag at the C-terminus and a Flag tag at the C-terminus followed by an Avi tag (Avitag™) . The protein has a calculated MW of 60.5 kDa.

Expression Region

Asp 2 - Ser 345

Host

HEK293

Target

CCR8

Conjugation

Biotin-labeled

Tag

C-10xHis & C-Flag & C-Avi

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Biotinylated Human CCR8 Protein, His,Flag Tag&Avitag (Cat. No. CC8-H82D3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-CCR8 Antibody, Human IgG1 with a linear range of 0.2-31 ng/mL (QC tested).

Format

Liquid

Buffer

50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5

Additives

Glycerol

Molecular Weight

60.5 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Dry ice

Storage Conditions

-70°C

Package Size

100ug*1

Host or Source

HEK293

Species

Human

Preservative

Glycerol

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