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Atorvastatin (hemicalcium salt)

Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

Product Specifications

CAS Number

[134523-03-8]

Product Name Alternative

CI-981; Atorvastatin hemicalcium

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Ferroptosis; HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/atorvastatin-hemicalcium-salt.html

Purity

99.94

Solubility

DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL

Smiles

FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]

Molecular Formula

C33H34Ca0.5FN2O5

Molecular Weight

577.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149 (1) :14-22.|[2]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50 (4) :458-61.|[3]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15 (5) : p. 678-82.|[4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8 (7) :564-72.|[5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12 (4) :e0174821.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Arch Biochem Biophys. 2025 Jan 21:765:110316.|bioRxiv. 2024 Jul 3:2024.07.01.601474.|Cell Death Dis. 2021 May 13;12 (5) :482.|Endocrinology. 2018 May 1;159 (5) :2008-2021.|Free Radic Biol Med. 2024 Aug 1:220:179-191.|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Nat Metab. 2025 Sep 22.|Pharmaceutics. 2022 Jan 12;14 (1) :176.|Acta Diabetol. 2025 Mar 27.|Acta Pharmacol Sin. 2024 Jun;45 (6) :1316-1320.|Arterioscler Thromb Vasc Biol. 2022 May;42 (5) :644-658.|Biomed Pharmacother. 2023 Oct:166:115323.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cancer Lett. 2023 Jan 1:552:215976.|Cell Cycle. 2019 Dec;18 (23) :3337-3350.|Cell Cycle. 2021 Oct;20 (20) :2160-2173.|Chem Biol Interact. 2025 Oct 22:420:111671.|Clin Pharmacol Ther. 2025 Jul 14.|Emerg Microbes Infect. 2025 Dec;14 (1) :2470371.|Endocrinology. 2022 Jul 1;163 (7) :bqac076.|Environ Sci Technol Lett. 2025 Apr 8.|Eur J Pharmacol. 2023 Oct 5:956:175938.|Eur J Pharmacol. 2024 Feb 5:964:176261.|Eur J Pharmacol. 2025 Feb 5:177357.|Exp Cell Res. 2023 Dec 15;433 (2) :113829.|Exp Neurol. 2025 May 16:115305.|FEBS Open Bio. 2025 Aug 8.|Front Cell Dev Biol. 2022 Mar 3;10:806081.|Front Pharmacol. 2025 Apr 30:16:1573032.|Inflammation. 2024 Oct 31.|Int Immunopharmacol. 2025 Dec 3:166:115644.|Int J Mol Sci. 2023 Apr 19;24 (8) :7492.|J Appl Toxicol. 2024 Apr 19|J Appl Toxicol. 2024 Aug;44 (8) :1198-1213.|J Mol Neurosci. 2022 Mar;72 (3) :565-573.|J Nat Prod. 2022 Jul 22;85 (7) :1738-1750.|J Neuroimmunol. 2020 Oct 24:350:577429.|J Tradit Complement Med. 2024 Mar 29.|Life Sci. 2025 Jun 1:370:123571.|Med Gas Res. 2025 Mar 1;15 (1) :148-155.|MedComm (2020) . 2024 Aug 31;5 (9) :e681.|Mol Cell. 2021 Jul 1;81 (13) :2736-2751.e8.|Nat Aging. 2025 Aug 26.|Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396 (12) :3659-3670.|Oncogene. 2022 Dec;41 (49) :5266-5278.|Oncologie. 2025 May 26.|Orebro University. 2024.|Phytomedicine. 2023 Jul 26;119:154997.|Phytomedicine. 2025 Jul:142:156713.|Phytomedicine. 2025 Oct:146:157128.|Proteomics. 2023 Aug;23 (16) :e2300041.|Research Square Preprint. 2021 Dec.|Research Square Preprint. 2022 Jun.|Research Square Preprint. 2024 Apr 9.|Sci Rep. 2020 Jan 28;10 (1) :1308.|Signal Transduct Target Ther. 2023 Dec 25;8 (1) :457.|Signal Transduct Target Ther. 2025 Nov 12;10 (1) :366.|SSRN. 2025 Apr 9.

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