PE-Labeled Human CD79B Protein, His Tag (Site-specific conjugation)

PE-Labeled Human CD79B, His Tag (CDB-HP2H6) is produced via site-specific conjugation of PE to Human CD79B, His Tag under optimal conditions with a proprietary technology. Human CD79B, His Tag is expressed from human 293 cells (HEK293) . It contains AA Ala 29 - Asp 159 (Accession # P40259-1) .

Product Specifications

Background

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type (immunoglobulin-like) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) .CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.8 kDa.

Accession Number

P40259-1

Expression Region

Ala 29 - Asp 159

Host

HEK293

Target

CD79B

Conjugation

PE Labeled

Tag

C-10xHis

Source

Human

Applications

Please note that this product is NOT compatible to streptavidin detection system.

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.