CGI-1746
Product Specifications
UNSPSC Description
CGI-1746 is a potent and highly selective inhibitor of the?Btk?with?IC50?of 1.9 nM.
Target Antigen
Autophagy; Btk
Type
Reference compound
Related Pathways
Autophagy;Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CGI-1746.html
Purity
99.39
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC=C(C=C1)C(C)(C)C)NC2=CC=CC(C(N=C3NC4=CC=C(C=C4)C(N5CCOCC5)=O)=CN(C3=O)C)=C2C
Molecular Weight
579.69
References & Citations
[1]Di Paolo, Julie A. et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nature Chemical Biology (2011), 7(1), 41-50|[2]Kokabee L, et al. Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol Ther. 2015;16(11):1604-15
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-11999/CGI-1746-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-11999/CGI-1746-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
910232-84-7
Available Sizes
Curated Selection
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