CGI-1746

CGI-1746 is a potent and highly selective inhibitor of the Btk with IC50 of 1.9 nM.

Product Specifications

CAS Number

[910232-84-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Btk

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/CGI-1746.html

Concentration

10mM

Purity

99.39

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=CC=C(C=C1)C(C)(C)C)NC2=CC=CC(C(N=C3NC4=CC=C(C=C4)C(N5CCOCC5)=O)=CN(C3=O)C)=C2C

Molecular Formula

C34H37N5O4

Molecular Weight

579.69

Precautions

H302

References & Citations

[1]Di Paolo, Julie A. et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nature Chemical Biology (2011), 7 (1), 41-50|[2]Kokabee L, et al. Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol Ther. 2015;16 (11) :1604-15