CGI-1746
CGI-1746 is a potent and highly selective inhibitor of the Btk with IC50 of 1.9 nM.
Product Specifications
CAS Number
[910232-84-7]
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Btk
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CGI-1746.html
Concentration
10mM
Purity
99.39
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC=C(C=C1)C(C)(C)C)NC2=CC=CC(C(N=C3NC4=CC=C(C=C4)C(N5CCOCC5)=O)=CN(C3=O)C)=C2C
Molecular Formula
C34H37N5O4
Molecular Weight
579.69
Precautions
H302
References & Citations
[1]Di Paolo, Julie A. et al. Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nature Chemical Biology (2011), 7 (1), 41-50|[2]Kokabee L, et al. Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol Ther. 2015;16 (11) :1604-15
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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