Compound E (GMP)

Compound E (GMP) is a GMP-grade Compound E (HY-14176) . GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a γ-secretase inhibitor. Compound E inhibits β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage with IC50 values of 0.24, 0.37, and 0.32 nM, respectively[1][2].

Product Specifications

CAS Number

[209986-17-4]

Product Name Alternative

γ-Secretase-IN-1 (GMP)

UNSPSC

12352005

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/compound-e-gmp.html

Smiles

FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1

Molecular Formula

C27H24F2N4O3

Molecular Weight

490.50

References & Citations

[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel γ-secretase inhibitor: implications for presenilin biology[J]. Journal of Biological Chemistry, 2001, 276 (48) : 45394-45402.|[2]Rasul S, et al. Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells[J]. British journal of cancer, 2009, 100 (12) : 1879-1888.