RG7713

RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a) .

Product Specifications

CAS Number

[920022-47-5]

Product Name Alternative

RO5028442

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/RO5028442.html

Purity

99.92

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(C(C=CC=C5)=C5CO4)CC3

Molecular Formula

C25H28ClN3O2

Molecular Weight

437.96

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58 (5) :2275-89.