CRI9
CRI9 inhibits the c-MET/PI3K/Akt/mTOR pathway, suppressing the growth of liver cancer cells. CRI9 shows strong cytotoxicity against HCC cells, inducing apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; c-Met/HGFR; mTOR; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cri9.html
Smiles
O=C(C1=CC=CC=C1N/2)C2=C3C(N(CC4=CN(C5=CC([N+]([O-])=O)=CC=C5C)N=N4)C6=C\3C=CC=C6)=O
Molecular Formula
C26H18N6O4
Molecular Weight
478.46
References & Citations
[1]Shalini V Gowda, et al. A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma. J Adv Res. 2024 Aug 30:S2090-1232 (24) 00377-1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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