CRI9

CRI9 inhibits the c-MET/PI3K/Akt/mTOR pathway, suppressing the growth of liver cancer cells. CRI9 shows strong cytotoxicity against HCC cells, inducing apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; c-Met/HGFR; mTOR; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cri9.html

Smiles

O=C(C1=CC=CC=C1N/2)C2=C3C(N(CC4=CN(C5=CC([N+]([O-])=O)=CC=C5C)N=N4)C6=C\3C=CC=C6)=O

Molecular Formula

C26H18N6O4

Molecular Weight

478.46

References & Citations

[1]Shalini V Gowda, et al. A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma. J Adv Res. 2024 Aug 30:S2090-1232 (24) 00377-1.