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Sinensetin

Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.

Product Specifications

CAS Number

2306-27-6

Product Name Alternative

Pedalitin permethyl ether

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PGE synthase; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Sinensetin.html

Concentration

10mM

Purity

99.62

Solubility

DMSO : 18.18 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(OC)=C(OC)C(OC)=C13

Molecular Formula

C20H20O7

Molecular Weight

372.37

Precautions

H302, H315, H319

References & Citations

[1]Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38 (4) :552-8.|[2]Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.
 Biosci Biotechnol Biochem. 2012;76 (4) :847-9.|[3]Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56 (6) :945-56.|[4]Kok-Tong Tan, et al. Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma. Anticancer Drugs. 2019, 30, 5.|[5]Mirka Laavola, et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med. 2012, 78, 8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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