Sinensetin
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.
Product Specifications
CAS Number
[2306-27-6]
Product Name Alternative
Pedalitin permethyl ether
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PGE synthase; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Sinensetin.html
Concentration
10mM
Purity
99.62
Solubility
DMSO : 18.18 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(OC)=C(OC)C(OC)=C13
Molecular Formula
C20H20O7
Molecular Weight
372.37
Precautions
H302, H315, H319
References & Citations
[1]Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38 (4) :552-8.|[2]Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.
 Biosci Biotechnol Biochem. 2012;76 (4) :847-9.|[3]Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56 (6) :945-56.|[4]Kok-Tong Tan, et al. Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma. Anticancer Drugs. 2019, 30, 5.|[5]Mirka Laavola, et al. Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. Planta Med. 2012, 78, 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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