MK-8245

MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy[1].

Product Specifications

CAS Number

[1030612-90-8]

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Stearoyl-CoA Desaturase (SCD)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/MK-8245.html

Purity

99.04

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(CN1N=C(N=N1)C2=CC(N3CCC(CC3)OC4=CC(F)=CC=C4Br)=NO2)O

Molecular Formula

C17H16BrFN6O4

Molecular Weight

467.25

Precautions

H302, H410

References & Citations

[1]Oballa RM, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54 (14) :5082-96. Epub 2011 Jun 28.