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PROTAC CDK9 degrader-9

PROTAC CDK9 degrader-9 (compound 29) is a highly selective and efficient CDK9 degrader based on PROTAC technology. PROTAC CDK9 degrader-9 can be used in anti-cancer research[1].

Product Specifications

UNSPSC

12352005

Target

CDK; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-cdk9-degrader-9.html

Purity

99.25

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=C(F)C(N(CC4)CCN4C5CCN(C(NC6=CC=C(CNC7=NC(N[C@H](CO)CC)=NC8=C(C(C)C)C=NN87)C=C6)=O)CC5)=C3)=O

Molecular Formula

C42H51FN12O6

Molecular Weight

838.93

References & Citations

[1]Nie HJ, et al. Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer. Bioorg Chem. 2024 Oct 9;153:107876.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-168518/PROTAC-CDK9-degrader-9-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-168518/PROTAC-CDK9-degrader-9-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK9

Available Sizes

Curated Selection

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