PROTAC JAK1 degrader 1

PROTAC JAK1 degrader 1 degrader 1 (compound 10c) is an effective and selective PROTAC JAK1 degrader with a DC50 of 214 nM. PROTAC JAK1 degrader 1 has antitumor activity. (Structure Note: PINK, JAK1 ligand 1 (HY-10961) ; Blue, VHL ligand Thalidomide (HY-14658) ; Black, linker) [1].

Product Specifications

CAS Number

[3052553-20-2]

UNSPSC

12352005

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-jak1-degrader-1.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCC(C(NCCCCC#CC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)CC4)C=C3)=NC=C2)C=C1

Molecular Formula

C44H41N9O6

Molecular Weight

791.85

References & Citations

[1]Zhang X, et al. Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities. Bioorg Med Chem Lett. 2024 Sep 1;109:129838.