MX106-4C
MX106-4C is a survivin inhibitor that selectively kills ABCB1-positive colorectal cancer cells. MX106-4C can exert synergistic anticancer effects with Doxorubicin or resensitize drug-resistant ABCB1 cells to Doxorubicin[1].
Product Specifications
UNSPSC
12352005
Target
Survivin
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mx106-4c.html
Purity
98.0
Solubility
DMSO : 8 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C(CN2CCCC2)C=C(COCC3=CC=C(C)C=C3Br)C4=CC=CN=C41
Molecular Formula
C23H25BrN2O2
Molecular Weight
441.36
References & Citations
[1]Lei ZN, et al. ABCB1-dependent collateral sensitivity of multidrug-resistant colorectal cancer cells to the survivin inhibitor MX106-4C. Drug Resist Updat. 2024 Mar;73:101065.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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