(8R)-8-Hydroxyepoxyboetirane A
Product Specifications
UNSPSC Description
(8R)-8-Hydroxyepoxyboetirane A is a neurogenic compound that interacts with PKC δ-C1B. (8R)-8-Hydroxyepoxyboetirane A binds to the PKC enzyme pocket via hydrogen bonds with Gly-253, Leu-251 and Thr242. (8R)-8-Hydroxyepoxyboetirane A induces NRG1 release and differentiation of NSC into neurons. (8R)-8-Hydroxyepoxyboetirane A is promising for research of neurological disorders[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8r-8-hydroxyepoxyboetirane-a.html
Smiles
C/C1=C\[C@]2([H])[C@](C2(C)C)([H])[C@H](O)C[C@]3(CO3)[C@H](OC(C)=O)[C@@]4([H])[C@@H](OC(C)=O)[C@@H](C)C[C@]4(OC(C)=O)C1=O
Molecular Weight
492.56
References & Citations
[1]Escobar-Montaño F, et al. Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies. Bioorg Chem. 2024 Aug 30;153:107769.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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