Bronopol

Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria) . Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser[2][3].

Product Specifications

CAS Number

[52-51-7]

Product Name Alternative

BNPD; BNPK

UNSPSC

12352211

Hazard Statement

H302, H312, H315, H318, H335, H400, H410

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Bronopol.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OCC([N+]([O-])=O)(Br)CO

Molecular Formula

C3H6BrNO4

Molecular Weight

199.99

Precautions

H302, H312, H315, H318, H335, H400, H410

References & Citations

[1]Shepherd JA, et al. Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol) . Antimicrob Agents Chemother. 1988 Nov;32 (11) :1693-8.|[2]Kireche M, et al., Evidence for chemical and cellular reactivities of the formaldehyde releaser bronopol, independent of formaldehyde release. Chem Res Toxicol. 2011 Dec 19;24 (12) :2115-28.|[3]Nieminen L, et al., The pain aggression induced by bronopol in the rat. Acta Pharmacol Toxicol (Copenh) . 1975 Sep;37 (3) :237-41.|[4]Bryce D M, et al. The activity and safety of the antimicrobial agent bronopol (2-bromo-2-nitropropan-1, 3-diol) [J]. J. Soc. Cosmet. Chem, 1978, 29: 3-24.