Glutarimide-Isoindolinone-NH-PEG4-COOH

Glutarimide-Isoindolinone-NH-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2927334-86-7]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/glutarimide-isoindolinone-nh-peg4-cooh.html

Purity

99.52

Solubility

DMSO : 180 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=C(C=C2CN1C3C(NC(CC3)=O)=O)NCCOCCOCCOCCOCCC(O)=O

Molecular Formula

C24H33N3O9

Molecular Weight

507.53

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1006.