Granulocyte Chemotactic Protein-2/CXCL6 (Human)

<strong>Granulocyte Chemotactic Protein-2/CXCL6 (Human)</strong>_x000D_ <strong>Catalog number:</strong> B2010271_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Granulocyte Chemotactic Protein-2/CXCL6, expressed in CHO cells. This protein acts as a chemokine produced by macrophages as well as epithelial and mesenchymal cells during an inflammation reaction._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuGCP-2/CXCL6; CKA-3; SCYB6_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Van Damme J, Wuyts A, Froyen G, Van Coillie E, Struyf S, Billiau A, Proost P,_x000D_ Wang JM, Opdenakker G. Granulocyte chemotactic protein-2 and related CXC_x000D_ chemokines: from gene regulation to receptor usage. J Leukoc Biol. 1997_x000D_ Nov;62(5):563-9._x000D_ _x000D_ 2: Kebschull M, Demmer R, Behle JH, Pollreisz A, Heidemann J, Belusko PB,_x000D_ Celenti R, Pavlidis P, Papapanou PN. Granulocyte chemotactic protein 2_x000D_ (gcp-2/cxcl6) complements interleukin-8 in periodontal disease. J Periodontal_x000D_ Res. 2009 Aug;44(4):465-71._x000D_ _x000D_ 3: Wuyts A, D'Haese A, Cremers V, Menten P, Lenaerts JP, De Loof A, Heremans H,_x000D_ Proost P, Van Damme J. NH2- and COOH-terminal truncations of murine granulocyte_x000D_ chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic_x000D_ potency. J Immunol. 1999 Dec 1;163(11):6155-63._x000D_ _x000D_ 4: D'Haese A, Wuyts A, Dillen C, Dubois B, Billiau A, Heremans H, Van Damme J,_x000D_ Arnold B, Opdenakker G. In vivo neutrophil recruitment by granulocyte_x000D_ chemotactic protein-2 is assisted by gelatinase B/MMP-9 in the mouse. J_x000D_ Interferon Cytokine Res. 2000 Jul;20(7):667-74._x000D_ _x000D_ 5: Wolf M, Delgado MB, Jones SA, Dewald B, Clark-Lewis I, Baggiolini M._x000D_ Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2._x000D_ Eur J Immunol. 1998 Jan;28(1):164-70._x000D_ _x000D_ 6: Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A,_x000D_ Oppenheim JJ, Proost P, Van Damme J. Characterization of synthetic human_x000D_ granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2_x000D_ and in vivo inflammatory properties. Biochemistry. 1997 Mar 4;36(9):2716-23._x000D_ _x000D_ 7: Zhu YM, Bagstaff SM, Woll PJ. Production and upregulation of granulocyte_x000D_ chemotactic protein-2/CXCL6 by IL-1beta and hypoxia in small cell lung cancer._x000D_ Br J Cancer. 2006 Jun 19;94(12):1936-41._x000D_ _x000D_ 8: Singh UP, Singh S, Boyaka PN, McGhee JR, Lillard JW Jr. Granulocyte_x000D_ chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta_x000D_ interactions. J Leukoc Biol. 2004 Dec;76(6):1240-7._x000D_ _x000D_ 9: Wuyts A, Haelens A, Proost P, Lenaerts JP, Conings R, Opdenakker G, Van Damme_x000D_ J. Identification of mouse granulocyte chemotactic protein-2 from fibroblasts_x000D_ and epithelial cells. Functional comparison with natural KC and macrophage_x000D_ inflammatory protein-2. J Immunol. 1996 Aug 15;157(4):1736-43._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18443119/">10: Linge HM, Collin M, Nordenfelt P, Mörgelin M, Malmsten M, Egesten A. The_x000D_ human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses_x000D_ membrane-disrupting properties and is antibacterial. Antimicrob Agents_x000D_ Chemother. 2008 Jul;52(7):2599-607. </a>_x000D_ _x000D_ <strong>Products Related to Granulocyte Chemotactic Protein-2/CXCL6 (Human) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>