HTL14242

HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively[1]. HTL14242 can be used for the research of parkinson’s disease[2].

Product Specifications

CAS Number

[1644645-32-8]

Product Name Alternative

HTL0014242

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/htl14242.html

Purity

98.58

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

N#CC1=CC(C2=NC=NC(C3=NC=C(F)C=C3)=C2)=CC(Cl)=C1

Molecular Formula

C16H8ClFN4

Molecular Weight

310.71

References & Citations

[1]Kirstie A Bennett, et al. Structure-based Discovery and Development of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Adv Pharmacol. . 2020;88:35-58.|[2]John A Christopher, et al. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6- (5-fluoropyridin-2-yl) pyrimidin-4-yl]benzonitrile) . J Med Chem. . 2015 Aug 27;58 (16) :6653-64.