Diheptanoyl Thio-PC

Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH) .1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.

Product Specifications

CAS Number

[89019-63-6]

UNSPSC

12352211

Hazard Statement

H225-H350

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/diheptanoyl-thio-pc.html

Smiles

C[N+](C)(C)CCOP(OC[C@H](SC(CCCCCC)=O)CSC(CCCCCC)=O)([O-])=O

Molecular Formula

C22H44NO6PS2

Molecular Weight

513.69

Precautions

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501

References & Citations

[1]Hendrickson, et al. Chiral synthesis of a dithiolester analog of phosphatidylcholine as a substrate for the assay of phospholipase A2. J. Lipid Res. 24 (11), 1532-1537 (1983) .