SJF-1528 (hemihydrate)
SJF-1528 (PROTAC 1) hemihydrate is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. SJF-1528 hemihydrate promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein ; Black: linker Tos-PEG2-CH2-Boc (HY-130532) ; Blue: ligand for E3 ligase (S, R, S) -AHPC (HY-125845) ).
Product Specifications
UNSPSC
12352005
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sjf-1528-hemihydrate.html
Purity
98.90
Solubility
DMSO : 104 mg/mL (ultrasonic;warming)
Smiles
Molecular Formula
C55H57ClFN7O8S.1/2H2O
Molecular Weight
1039.62
References & Citations
[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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